Welcome! We are a computational biophysics group focused on the structure, dynamics, and function of heterogeneous biomolecular assemblies, particularly those involving complex protein-lipid interactions.

We leverage all-atom and coarse-grained molecular dynamics simulations to investigate systems critical to human health, including human low-density lipoprotein (LDL) and bacterial chemosensory arrays, providing high-resolution mechanistic insights into macromolecular and cellular function.

We also develop and apply advanced integrative modeling methods, typically involving cryo-electron microscopy data, to construct high-fidelity models of experimentally challenging systems, strengthening the ability to discern function from structure and rendering these systems amenable to dynamic characterization in silico.